29 citations
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December 2016 in “The EMBO Journal” This study found that the transcription factor Gata6 plays a crucial role in adult mouse hair follicle regeneration by promoting the renewal and preventing DNA damage of rapidly proliferating progenitor cells.
2 citations
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February 2025 in “Journal of Investigative Dermatology” In this study, researchers used quantitative fate mapping to investigate how the infundibulum, part of the epidermis, is maintained during adulthood, finding that progenitors maintain this tissue through stochastic cell fate choices, with cells at the bottom providing transient support during hair growth phases.
200 citations
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March 2023 in “Nature Reviews Molecular Cell Biology” This review discusses the role and regulation of quiescent adult stem cells in tissue maintenance and repair, focusing on molecular mechanisms and their implications for regenerative medicine, but reports no new clinical results.
105 citations
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April 2005 in “Cell” This article discusses recent findings on hair graying involving melanocyte stem cell maintenance and key regulatory molecules, and reports no new experimental results.
26 citations
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July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.