July 2008 in “International journal of psychophysiology” Cyproterone acetate is a safe treatment that causes mild feminizing effects in adolescent trans-girls.
August 2020 in “Nigerian journal of paediatrics” A 24-month-old Nigerian girl developed early puberty with no family history, needing treatment her family couldn't afford.
32 citations
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September 2018 in “Clinical Obstetrics and Gynecology” Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.
88 citations
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September 2003 in “Clinical endocrinology” Hormone treatment for transsexual individuals is effective but carries risks like thromboembolic events and mood changes, with most side effects being minor and reversible.
36 citations
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May 2017 in “The journal of sexual medicine” Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.