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    GlossaryCitrullus colocynthis (bitter apple)

    desert plant known as bitter apple with potent medicinal properties

    Citrullus colocynthis, also known as bitter apple or colocynth, is a desert plant in the Cucurbitaceae family. It produces a small, hard fruit that has been traditionally used in herbal medicine for its strong laxative properties. However, due to its potent bioactive compounds, it should be used with caution as it can be toxic in high doses.

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      community Regrowth after 3 months. Min only

      in Is this regrowth?  150 upvotes 2 days ago
      A 38-year-old man is using topical and oral Minoxidil, DHT blocker shampoo, and microneedling for hair regrowth, with plans to add Finasteride later. Many users suggest starting Finasteride or Dutasteride immediately to address the root cause of hair loss, while some express concerns about potential side effects.

      community The meds work: my dad at 23 yo vs me at 35 yo

      in Finasteride/Dutasteride  1748 upvotes 2 weeks ago
      Finasteride and oral minoxidil effectively maintain a youthful appearance and full head of hair, despite genetic predispositions to balding. The discussion also considers the impact of DHT blockers on masculinity and aging, with lifestyle choices like sunscreen use and a vegetarian diet mentioned.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  732 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community The theory that explains everything. Please help me make this big!

      in Research/Science  2447 upvotes 4 years ago
      The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.