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This study examined skin biopsies from a woman with Addison disease and found melanocytic hyperpigmentation in the epidermis, with a notable melanocyte/keratinocyte ratio indicating increased melanocyte presence in the arm compared to the thigh.

In this case study, the researchers reported a rare incidence of bilateral hyperpigmented macules on a patient's lower legs, possibly due to cyclophosphamide, suggesting that this chemotherapy drug may directly stimulate hair follicles to cause skin discoloration.

This study concludes that tiny infundibular cysts, rather than comedones, are the primary lesions in chloracne.

This article discusses pigmentation disorders in veterinary dermatology, focusing on the role of melanogenic pigmentation, and reports no new research results.

Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.