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research GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk

April 2020

This genome-wide association study of over 70,000 men identified 71 genetic loci linked to male pattern baldness, highlighting pathways that could help explain its underlying biology.

research Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss

38 citations , February 2012 in “British Journal of Dermatology”

This study suggests that the AR/EDA2R locus may contribute to early-onset female pattern hair loss, but no association was found with the 20p11 locus.

research Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study

April 2024 in “Human genomics”

This study identified MPB susceptibility genes and potential drug candidates that may help uncover molecular mechanisms and address male-pattern baldness.

research Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness

51 citations , November 2011 in “British Journal of Dermatology”

This study suggests that the HDAC9 gene is a third susceptibility gene for male-pattern baldness, with significant associations found in both German and Australian samples.

research Prioritizing Susceptibility Genes for the Prognosis of Male-pattern Baldness with Transcriptome-wide Association Study

January 2024 in “Research Square (Research Square)”

This study identified robust susceptibility genes and potential drug candidates for male-pattern baldness, providing insights into the condition's molecular mechanisms.

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community M25: Getting way too many DMs, so let’s do this here! AMA about Male Pattern Baldness, Hair Loss, and Products (100% Science-Backed )

1951 upvotes 5 months ago

Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.

community Still not sure why men think diet has nothing to do with hair loss when scientific is quite the opposite [Link]

23 upvotes 8 years ago

Diet can influence hair health, but male pattern baldness (MPB) is primarily genetic. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Kintor’s KX-826 Pyrilutamide!!

152 upvotes 4 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Hair Loss Treatments On a Budget, A Scientific Approach (Topical Finasteride, Minoxidil, Tretinoin, Castor + Peppermint Oil and more)

8 upvotes 10 years ago

The conversation discusses affordable hair loss treatments, including topical finasteride, minoxidil, tretinoin, and natural remedies like castor and peppermint oil. Specific treatments for hair loss are the focus.

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Hair Transplant

What causes male pattern baldness? Male pattern baldness is caused by genetic sensitivity to the hormone DHT.
What is male pattern baldness? Male pattern baldness is a genetic condition causing hair loss in men, starting with a receding hairline.
Can male pattern baldness be prevented? Male pattern baldness cannot be completely prevented, but treatments can slow its progression.

learn Nanoxidil

Can Nanoxidil help with both male and female pattern baldness? Nanoxidil may help with both male and female pattern baldness, but lacks FDA approval.

learn RU58841

Is RU58841 magic or a scam? Does it really stop baldness? RU58841 is an unapproved research chemical: the published evidence is animal and lab work from the 1990s, there has never been a controlled human trial for hair loss, and nothing sold online is quality-controlled — so its effect and its long-term safety in people are both unknown.

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