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GlossaryAromatase Inhibitors

block estrogen production by inhibiting the aromatase enzyme

Aromatase Inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels, AIs are commonly used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women, as estrogen can promote the growth of certain types of breast cancer cells.

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Androgenic Efficacy and Mechanism of Glycosides-Based Standardized Fenugreek Seeds Extract Through Aromatase and 5-Alpha Reductase Inhibition

research Androgenic Efficacy and Mechanism of Glycosides-Based Standardized Fenugreek Seeds Extract Through Aromatase and 5-Alpha Reductase Inhibition

1 citations , February 2024 in “Pharmacognosy Journal”

Fenugreek seed extract boosts testosterone and improves male reproductive health without heart side effects.

research A Comprehensive Review on Phytochemistry and Pharmacological Effects of Stinging Nettle (Urtica dioica)

8 citations , May 2017 in “Current traditional medicine”

Stinging nettle has compounds that help with joint pain, arthritis, and prostate issues.

Early Androgen Activity After Birth Determines the Hypothalamic Expression of Androgen and Estrogen Receptors in Adulthood in Female but Not in Male Rats

research Early Androgen Activity After Birth Determines the Hypothalamic Expression of Androgen and Estrogen Receptors in Adulthood in Female but Not in Male Rats

July 2025 in “Reproductive Biology and Endocrinology”

Early androgen exposure affects hormone receptor expression in adult female rats' brains, but not in males.

research Aromatase Inhibition by Letrozole Attenuates Kainic Acid-Induced Seizures but Not Neurotoxicity in Mice

11 citations , April 2018 in “Epilepsy research”

Letrozole reduces seizures but not brain damage in mice.

research Selective Inhibition of 5α-Reductase and Preservation of Aromatase in Hair Transplantation

February 2026 in “Revista Eletrônica Polidisciplinar Voos.”

A balanced approach using dutasteride and Serenoa repens can improve hair transplant success by protecting follicles and minimizing side effects.

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community Has anyone ever used grape seed extract? Any negative effects on hair ?

in Treatment 6 upvotes 4 years ago

The conversation is about the effects of grape seed extract on hair, with mixed experiences reported. One user advises against using it.

community One year off fin/min and I regret it

in Update 421 upvotes 6 months ago

The user regrets stopping finasteride and minoxidil due to side effects but plans to resume treatment. They consider using finasteride every other day and continuing topical minoxidil to manage side effects while maintaining hair.

community My hair loss journey, natural DHT blocker first then Finasteride 1mg every day.

in Progress Pictures 152 upvotes 1 year ago

The user experienced hair regrowth and stopped hair loss using a natural DHT blocker and later finasteride, despite initial side effects. They plan to add topical minoxidil to address remaining thin spots.

community Finasteride , creatine and muscle growth

in Finasteride/Dutasteride 28 upvotes 1 year ago

Finasteride does not significantly affect muscle gains and can slightly increase testosterone levels. Creatine is generally considered safe to use with finasteride, though some believe it may increase DHT levels, potentially affecting hair loss.

community Dutasteride vs Finasteride and Steroid

in Progress Pictures 87 upvotes 5 months ago

Dutasteride is preferred over finasteride for hair loss due to fewer side effects. Combining dutasteride with minoxidil and RU58841 is effective for hair regrowth, even during steroid use.

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