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    GlossaryAntinuclear Antibody

    autoantibodies targeting cell nuclei, often indicating autoimmune diseases

    Antinuclear Antibody (ANA) refers to a type of autoantibody that targets substances found in the nucleus of cells. These antibodies are often present in individuals with autoimmune diseases, such as lupus or rheumatoid arthritis, and their presence can be detected through a blood test to help diagnose these conditions.

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      research Tuberculosis Mimicking the Onset of Systemic Lupus Erythematosus Flare: Case-Based Review

      1 citations, February 2023 in “International Journal of Rheumatic Diseases”
      This case-based review analyzed three instances of tuberculosis (TB) mimicking systemic lupus erythematosus (SLE) flare, with patients aged 27 to 32 years. These cases lacked typical SLE features like butterfly erythema, lupus hair, alopecia, or proteinuria. The study found that TB could induce the production of various autoantibodies, such as anti-nuclear and anti-double-stranded DNA antibodies, which are usually seen in SLE. However, these autoantibodies did not change the clinical or radiographic presentation of TB and were not present after the infection resolved. The resistance of SLE-like symptoms to steroid and immunosuppressive treatments suggested an infectious cause. The findings highlight the importance of considering active TB in patients with SLE-like symptoms, especially when specific serological markers and hypocomplementemia are present.

      research Abdominal Pain in a Young Woman With Systemic Lupus Erythematosus

      August 2023 in “The American Journal of Medicine”
      A 17-year-old female was diagnosed with systemic lupus erythematosus (SLE) after presenting with arthralgia, hair loss, Raynaud's phenomenon, malar rash, oral ulcers, and palmar erythema. Laboratory tests showed leukopenia, elevated erythrocyte sedimentation rate (90 mm/h), and positive anti-nuclear antibodies (ANA) among other specific antibodies. She was treated with hydroxychloroquine 200 mg twice a week and prednisone 15 mg/day.

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