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Did you mean Anti-double-stranded DNA antibody?

Glossary Anti-double-stranded DNA antibody

autoantibodies targeting DNA, linked to autoimmune diseases

Anti-double-stranded DNA (anti-dsDNA) antibodies are autoantibodies that specifically target the double-stranded form of DNA, often associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE). Their relevance to hair loss lies in the fact that autoimmune conditions can lead to hair loss through mechanisms such as inflammation and follicle damage. Key distinguishing characteristics of anti-dsDNA antibodies include their high specificity for SLE and their correlation with disease activity, making them important markers in both diagnosis and monitoring of the disease.

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research Tuberculosis mimicking the onset of systemic lupus erythematosus flare: Case based review

1 citations , February 2023 in “International Journal of Rheumatic Diseases”

This study reported that tuberculosis can mimic lupus-like symptoms, including the production of autoantibodies, which may confuse the diagnosis with systemic lupus erythematosus flares.

A Rare Case of Antinuclear Antibody-Negative Systemic Lupus Erythematosus Presenting With Generalized Lymphadenopathy as the Initial Manifestation

research A Rare Case of Antinuclear Antibody-Negative Systemic Lupus Erythematosus Presenting With Generalized Lymphadenopathy as the Initial Manifestation

October 2025 in “Cureus”

This case report highlights the diagnostic challenge of ANA-negative pediatric SLE in South Asia, emphasizing the need for comprehensive diagnostic criteria and clinical vigilance for early recognition and treatment.

research Abstract 10845: Spontaneous Coronary Artery Dissection as the Primary Presentation of Ana-Negative Lupus

November 2021 in “Circulation”

This case report highlights the first known instance of ANA-negative systemic lupus erythematosus presenting as spontaneous coronary artery dissection, emphasizing a need for rheumatological evaluation in such patients.

research Life threatening macrophage activation syndrome as the initial presentation of systemic lupus erythematosus: A case report and review of the literature

3 citations , November 2022 in “The Egyptian Rheumatologist”

This case report describes a rare instance where a young woman initially presented with macrophage activation syndrome as the first sign of systemic lupus erythematosus, and ultimately experienced multiorgan failure and death.

research Fever of unknown origin in a male patient with systemic lupus erythematosus.

January 2017 in “PubMed”

This case report describes a 21-year-old man diagnosed with systemic lupus erythematosus, highlighting the condition's potential to mimic hematological malignancy and the effectiveness of prednisolone in rapid symptom improvement.

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