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Impact of Anti-Androgen Therapies on COVID-19 Susceptibility: A Case-Control Study in Male Population from Two COVID-19 Regional Centers of Lombardy, Italy

research Impact of anti-androgen therapies on COVID-19 susceptibility: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy)

4 citations , April 2020 in “medRxiv (Cold Spring Harbor Laboratory)”

This case-control study from Lombardy, Italy, observed that men over 55 taking 5-alpha reductase inhibitors for benign prostatic hyperplasia were hospitalized for COVID-19 at a lower rate than age-matched controls, suggesting potential protective effects against severe disease.

research Therapeutic effect of finasteride through its antiandrogenic and antioxidant role in a propionic acid-induced autism model: Demonstrated by behavioral tests, histological findings and MR spectroscopy

3 citations , April 2022 in “Neuroscience Letters”

In this animal study, finasteride significantly improved autism-like symptoms in rats by reversing biochemical markers and enhancing behaviors, potentially due to its antioxidant and anti-androgen effects.

research Anti-androgen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies

May 2025 in “Journal of the American Academy of Dermatology”

This review highlights the available and investigational anti-androgen treatments for female pattern hair loss in the US, noting their limitations and the potential for fewer systemic side effects with topical options compared to oral medications.

research Antiandrogenic drugs, a therapeutic option for frontal fibrosing alopecia patients

10 citations , March 2016 in “Journal of The American Academy of Dermatology”

This review discusses the potential usefulness and safety profile of oral antiandrogens for treating frontal fibrosing alopecia, noting possible benefits but acknowledges that finasteride's efficacy remains uncertain.

research Androgen receptor: A promising therapeutic target in breast cancer

21 citations , March 2019 in “Critical Reviews in Clinical Laboratory Sciences”

This review discusses the role of the androgen receptor in breast cancer diagnosis and treatment, and notes a lack of new research results on its therapeutic potential.

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Community Join

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community I Get Side-Effects from Anti-Androgens

8 upvotes 6 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 1 year ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community When meds don't work how long is too soon before giving up?

7 upvotes 2 weeks ago

A user has been using finasteride, minoxidil, and microneedling for hair loss but continues to experience thinning and has been rejected for a hair transplant due to a thin donor region. They are considering switching to dutasteride and exploring other treatments like mesotherapy, PRP, and topical anti-androgens, while also contemplating shaving their head.

community 8 months of therapies, finasteride, minoxidil and more

in Progress Pictures 397 upvotes 5 months ago

The user experienced significant hair regrowth over 8 months using finasteride, minoxidil, and a custom topical mix including progesterone, cortisone, and alpha 5 estradiol. They reported no side effects and noticed improvement around the third month.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

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Learn

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learn Ketoconazole

antifungal with some anti-androgenic benefits, often used as a shampoo

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in both men and women, but it is not approved for hair loss anywhere; the company reports that its China Phase III trial in men met its primary endpoint, but the data come from sponsor announcements rather than peer-reviewed journals, and long-term safety is unknown.

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn HMI-115

HMI-115: Frequently Asked Questions About Hair Loss Treatment HMI-115 is an investigational anti-prolactin-receptor antibody being trialled for androgenetic alopecia. It is not approved anywhere; its hair-loss evidence is a 16-person Phase 1b announced only by press release, plus a completed 192-man Phase 2 in China whose results are not yet published.

learn Baicapil

Struggling with patchy hair loss like alopecia areata? Baicapil might help by reducing inflammation and reactivating growth. There is no published trial of Baicapil in alopecia areata. The anti-inflammatory and hair-density claims come from the ingredient's manufacturer and from laboratory work on its plant extracts, in people with androgenetic-type hair loss rather than autoimmune patchy hair loss.

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Clinics

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All 28 clinic results →

Experts

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16
Dermatologist
Andi Iryanti, M. Biomed
Indonesia

Andi Iryanti, M. Biomed