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5 / 47 resultslearn Ketoconazole
antifungal with some anti-androgenic benefits, often used as a shampoo
learn Minoxidil
An essential vasodilator with some anti-androgenic effects, has excellent safety record
learn Lavender
plant and natural oil with antimicrobial and some anti-androgenic effects
learn Finasteride
Frontline, gold standard treatment for combatting androgenic alopecia
Research
5 / 1000+ resultsresearch Neo-Synthesis of Estrogenic or Androgenic Neurosteroids Determine Whether Long-Term Potentiation or Depression Is Induced in Hippocampus of Male Rat
DHT is needed for long-term depression, while E2 is needed for full long-term potentiation in male rat brains.
research Inhibition of 17α-Hydroxylase/C17,20 Lyase Reduces Gating Deficits Consequent to Dopaminergic Activation
Blocking CYP17A1 enzyme may help improve certain brain function issues related to dopamine.
research Sex-Specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids
Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.
research Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders
Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.
research Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids
Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.
Community Join
5 / 1000+ resultscommunity A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors
Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.
community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?
Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.
community Binding affinity of pyrilutamide!
Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.
community Earliest we can get legitimate pyrilutamide
Pyrilutamide, a drug in phase 3 trials in China, potentially becoming available in late 2023 or early 2024; Finasteride being used as a current treatment for hair loss; and the possibility of joining a group buy for black market versions of Pyrilutamide.
community Sulforaphane Topical to Degrade DHT - For People Who Want to Try the Theory that Explains Everything
A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.