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research Phenytoin‐mediated androgen metabolism in gingival fibroblasts

8 citations , October 2002 in “Journal Of Clinical Periodontology”

This study suggests that levamisole and finasteride can significantly reduce DHT levels in human gingival fibroblasts, potentially addressing phenytoin-induced gingival overgrowth.

research Dutasteride‐mediated morphological changes in the genitourinary tract associated with altered expression patterns of the androgen and estrogen receptors in male rats

12 citations , November 2016 in “Andrology”

This study found that dutasteride treatment in male rats was associated with prostate and penis morphological changes and altered androgen and estrogen receptor expression patterns.

research Androgen receptor–mediated inhibition of cutaneous wound healing

207 citations , September 2002 in “The Journal of clinical investigation/The journal of clinical investigation”

The study found that reducing testosterone in male mice through castration or androgen antagonism significantly accelerated wound healing by decreasing inflammation, suggesting a potential therapeutic target for impaired healing in elderly men.

research Androgen receptor–mediated inhibition of cutaneous wound healing

108 citations , September 2002 in “The Journal of clinical investigation/The journal of clinical investigation”

This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.

research Androgen receptor–mediated inhibition of cutaneous wound healing

9 citations , September 2002 in “The Journal of clinical investigation/The journal of clinical investigation”

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community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community Has anyone powered through the creatine shedding (via increased androgen receptor sensitivity) and stabilized?

9 upvotes 1 year ago

Creatine may cause increased hair shedding due to androgen receptor sensitivity, despite limited evidence. The user is using dutasteride and minoxidil and seeks advice on whether shedding will stabilize, with suggestions including GHK-Cu and RU58841.

community How to deal with overproduction of sebum?

10 upvotes 1 month ago

The user is experiencing diffuse thinning and excessive sebum production, considering Accutane as a potential solution after trying dutasteride and oral minoxidil without success. Other users suggest treatments like Nizoral shampoo, finasteride, beclomethasone dipropionate lotion, and topical androgen receptor inhibitors.

community A new study by Deng and colleagues set out to explore differences between balding and non balding scalps...

39 upvotes 4 years ago

Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is an investigational topical androgen-receptor degrader. One 12-week Phase II trial in 180 Chinese men found two of four regimens beat placebo on hair count; it is not approved or available.

learn Spironolactone

Who is spironolactone used for in androgen-related hair thinning, and who should avoid it? Studies of spironolactone for hair loss are mostly in adult women; its use is off-label, it is avoided in pregnancy and generally not used in men, and the US label advises potassium checks (DailyMed, Aldactone).

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