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research A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study

November 2025 in “Archives of Dermatological Research”

This study found that Limelight (CB-EVs) exosomes significantly promoted hair elongation ex vivo without cytotoxicity, suggesting potential as a safe and effective hair growth therapy.

research A Comparison of Methods of Anagen Synchronization in the Adult Rat Model of Chemotherapy-Induced Alopecia

January 2015 in “Journal of clinical and investigative dermatology”

This study found that clipping is the most effective method for anagen synchronization in adult rat models to mimic chemotherapy-induced alopecia, producing robust anagen phases without causing skin trauma.

research A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

8 citations , October 2017 in “Dermatology practical & conceptual”

This study found that a spermidine-based nutritional supplement increased the number of anagen phase hair follicles in healthy humans, suggesting potential benefits for hair loss conditions.

research Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

January 2025 in “MEDS Public Health and Preventive Medicine”

In this study, oral spermidine supplementation was found to significantly prolong the hair follicle anagen phase and reduce hair loss, with effects persisting three months after treatment in healthy participants, suggesting potential therapeutic benefits for hair loss conditions.

research In vitro effects of testosterone, dihydrotestosterone and estradiol on cell growth of human hair bulb papilla cells and hair root sheath fibroblasts.

22 citations , July 1990 in “Acta Dermato Venereologica”

In this study, high concentrations of dihydrotestosterone and testosterone reduced the growth of human hair follicle cells in vitro, while high estradiol levels increased their growth.

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community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community Thoughts on this topical? Has a combination going on but are they really heavy hitters

4 upvotes 7 months ago

Follicium XR™ is a topical treatment for hair loss containing RU58841, AHK-Cu, GHK-Cu Peptide, caffeine, D-Biotin, methylene blue, keratin, and spermidine. RU58841 is considered the most effective ingredient, but concerns exist about its stability in water.

community Regrowth with only Nizoral and Lifestyle Changes; focusing on scalp health & nervous system

89 upvotes 7 months ago

The user reported subtle hair regrowth by focusing on scalp health and lifestyle changes, using Nizoral shampoo and methods to reduce inflammation and cortisol, without using finasteride, minoxidil, or other common treatments. Opinions in the conversation varied, with some skeptical of the results and others acknowledging the potential benefits of addressing scalp health and inflammation.

community Federal Grant Cuts have impacted PP405 related research

459 upvotes 1 year ago

Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.

community I interviewed Kintor: GT20029 Clinical Trial Pictures. As well as KX826.

156 upvotes 1 year ago

GT20029 and KX826 are promising hair loss treatments, with GT20029 increasing hair count and KX826 showing significant results. KX826 may be a good alternative for those who can't use finasteride or dutasteride, though results vary.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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