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research MANIFESTATIONS OF EXCESSIVE DAYTIME SLEEPINESS AND GHRELIN LEVEL IN CASE OF GASTROESOPHAGEAL REFLUX DISEASE IN PATIENTS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE

1 citations , January 2022 in “Wiadomości Lekarskie”

In this study, GERD symptoms were found to be significantly related to acid exposure time and the intensity of excessive daytime sleepiness, which depends on circulating ghrelin levels.

research Valproic Acid is an Effective Anti-Emetic Treatment in Alexander Disease (P10-9.010)

April 2023 in “Neurology”

This study examined treatments for emesis in young Alexander disease patients, finding that 95% responded positively to valproic acid, which was more effective than anti-reflux medications or cyproheptadine, though some adverse effects require monitoring.

research EFFECT OF ANTIANDROGENS ON VALPROIC ACID-INDUCED NEURODEVELOPMENTAL CHANGES IN RATS

July 2023 in “Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ”

The research investigated the effects of antiandrogens on neurodevelopmental milestones in rats exposed to valproic acid during pregnancy, finding that while valproic acid delayed sensorimotor reflexes, it didn't impact physical development milestones, and antiandrogens partially mitigated these delays.

research Embryo‐Fetal Developmental Toxicity and Toxicokinetics Studies of YWS1903, a Novel Potassium‐Competitive Acid Blocker, in Pregnant Rats

May 2025 in “Birth Defects Research”

This study investigated the effects of YWS1903 in pregnant rats and found that high doses led to fetal growth reduction and skeletal malformations, while lower doses did not cause significant issues, establishing a no observed adverse effect level at 60 mg/kg.

research Ultrasound and microwave assisted extraction of luteolin from Eclipta prostrata

1 citations , January 2013 in “African Journal of Pharmacy and Pharmacology”

This study found that ultrasound assisted microwave extraction was more efficient than other methods for extracting luteolin from Eclipta prostrata, reducing extraction time and simplifying the process.

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community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 year ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Best, possible, or experimental growth agonists that AREN'T MINOXIDIL.

4 upvotes 5 years ago

Various hair growth treatments were discussed, including microneedling, bimatoprost, setipiprant, stemoxydine, PGE2, CB-03-01, WNT Beta-Catenin upregulators, KY19382, topical estrogen, IGF-1, GH, MK-677, oral castor oil, fisetin, resveratrol, cetrizine, and lactic acid. Users shared experiences and sources for these treatments, with some expressing interest in topical solutions and others noting the lack of FDA approval or scientific evidence for certain options.

community Can hanging upsidedown regrow hair?

897 upvotes 3 months ago

Hanging upside down is suggested as a method to increase blood flow to the scalp for hair growth, but its effectiveness is questioned. Treatments mentioned include minoxidil, finasteride, biotin, estrogen, and scalp massage.

community The people this data actually matters for aren't talking about efficacy numbers

9 upvotes 5 months ago

Oral minoxidil can cause cardiovascular issues, but an extended release formulation may reduce side effects like heart rate and blood pressure spikes. This new formulation offers a safer option for those who previously had to stop due to health concerns.

community Hair Loss Results After 8 Months of Dutasteride

in Progress Pictures 233 upvotes 1 year ago

The user experienced increased hair density after 8 months of using dutasteride and 6 months of oral minoxidil. Some users joked about side effects, while others discussed the effectiveness of various treatments like finasteride and rosemary oil.

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learn Azelaic Acid

Acid used in acne and rosacea creams

Is azelaic acid a treatment on its own or does it need supplements? One small randomised trial (26 women, no placebo) found no significant difference between 5% azelaic acid and 2% minoxidil in female pattern hair loss, which is too small to show they work equally well, and the anti-DHT rationale otherwise rests on in-vitro work. Community members generally describe azelaic acid as an add-on to minoxidil or finasteride rather than a standalone treatment.
azelaic acid: Does it work for all types of hair loss or just DHT? One small randomised trial (26 women, no placebo) found no significant difference between 5% azelaic acid and 2% minoxidil for female pattern hair loss, which is too small to show they work equally well, and the anti-DHT rationale rests on laboratory work. For alopecia areata, telogen effluvium and seborrhoeic dermatitis there is no trial evidence for azelaic acid at all.
What happens if I mix azelaic acid with minoxidil or regular hair loss shampoos? No published study has tested azelaic acid combined with minoxidil or with hair-loss shampoos, and layering them can irritate the scalp. Mixing anything into a minoxidil solution changes the drug in untested ways, so ask a pharmacist before combining products.
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