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research Acid phosphatase distribution in the wool follicle. III. Fate of organelles in keratinized cells

6 citations , June 1976 in “Journal of ultrastructure research”

This study identified the presence of recognizable organelles, such as lysosomes and mitochondria, in both the keratinized fiber and the hardened inner root sheath of the Romney wool follicle.

research Distribution of acid and alkaline phosphatases in canine skin.

3 citations , December 1975 in “PubMed”

This study found that acid and alkaline phosphatases serve different functions in Beagle dog skin, with ALP primarily involved in growth processes and ACP in phospholipid breakdown.

research A comparative clinical study to assess the effectiveness of homoeopathic constitutional medicine and acid phos in the management of alopecia areata

July 2026 in “Journal of Homeopathy Studies”

This study observed greater clinical improvement in patients with alopecia areata who received individualized homoeopathic constitutional treatment compared to those who received Acid Phos, but further research with objective measures is needed to confirm these findings.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.

research Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

18 citations , October 2018 in “Nutrients”

This study found that Annurca apple polyphenolic extracts reprogram hair follicle metabolism in mice, enhancing mitochondrial activity and keratin production while inhibiting some metabolic pathways.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Thymosin Beta 4

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

Is azelaic acid a treatment on its own or does it need supplements? One small randomised trial (26 women) found 5% azelaic acid comparable to 2% minoxidil in female pattern hair loss, and the anti-DHT rationale otherwise rests on in-vitro work — community members generally describe azelaic acid as an add-on to minoxidil or finasteride rather than a standalone treatment.
azelaic acid: Does it work for all types of hair loss or just DHT? One small randomised trial (26 women) found 5% azelaic acid comparable to 2% minoxidil for female pattern hair loss, and the anti-DHT rationale rests on laboratory work; for alopecia areata, telogen effluvium and seborrhoeic dermatitis there is no trial evidence for azelaic acid at all.
What happens if I mix azelaic acid with minoxidil or regular hair loss shampoos? Mixing azelaic acid with minoxidil or hair loss shampoos is generally safe and may enhance effectiveness.
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learn Salicylic acid

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community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community P-1075: a BETTER version of Minoxidil

11 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community Korean minoxidil is superior to what we can get in the EU

261 upvotes 3 weeks ago

Korean minoxidil is preferred over Foligain due to its non-greasy, fast-drying formula that lacks propylene glycol, making it more pleasant to use. The user has been using minoxidil for over two years and finasteride for about ten months, but it's unclear how much the Korean minoxidil has contributed to their results.

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