Distribution of Acid and Alkaline Phosphatases in Canine Skin

    December 1975 in “ PubMed ”
    Conroy Jd, C. A. Green
    TLDR ALP and ACP have different roles in dog skin, with ALP aiding growth and maintenance, and ACP involved in breakdown processes.
    The study investigated the distribution of acid phosphatase (ACP) and alkaline phosphatase (ALP) in the skin of 25 Beagle dogs using azo dye methods. ALP activity was observed in various skin structures, including dermal papillae of hair follicles, Huxley's layer, myoepithelial cells of apocrine sweat glands, germinative cells of sebaceous glands, vascular endothelium, and mast cells. ACP activity was found in the epidermis, root sheaths, keratogenous zone, hair cuticle and medulla, duct of sebaceous gland, and sebum. The study concluded that ACP and ALP serve different biological functions, with ALP involved in dephosphorylation for growth and maintenance of the pilary system and glandular adnexa, while ACP is primarily involved in phospholipid breakdown and keratinocyte necrobiosis.
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