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GlossaryAcanthosis Nigricans

skin condition with dark, thick, velvety patches

Acanthosis Nigricans (AN) is a skin condition characterized by dark, thick, and velvety patches, typically found in body folds and creases such as the neck, armpits, and groin. It is often associated with insulin resistance, obesity, and hormonal disorders, and can sometimes be a sign of an underlying health issue like type 2 diabetes or, in rare cases, cancer.

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research Mania in Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome

3 citations , February 2002 in “The American journal of psychiatry”

Stopping birth control pills may have triggered a manic episode in a woman with HAIR-AN syndrome.

research Hyperandrogenism Insulin Resistance-Acanthosis Nigricans Syndrome in a Female Adolescent with Migraine: A Case Report

October 2025 in “Indian Journal of Physiology and Pharmacology”

Early diagnosis and treatment of endocrine disorders like HAIR-AN syndrome can improve outcomes in adolescents.

research Acanthosis Nigricans During HAIR-AN Syndrome: The Tree That Hides the Forest

January 2017 in “Journal of clinical & experimental dermatology research”

The case shows skin changes can indicate deeper health issues like insulin resistance, which are challenging to manage.

research Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome with PCOS and Hashimoto's Thyroiditis: Case Report

January 2015 in “International Journal of Research in Medical Sciences”

A patient with HAIR-AN syndrome, PCOS, and Hashimoto's thyroiditis improved with early diagnosis and treatment to prevent serious health problems.

research Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome

7 citations , January 2015 in “Case reports in endocrinology”

The document concludes that HAIR-AN syndrome should be considered when a patient shows severe hyperandrogenism and insulin resistance after excluding tumors.

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