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Glossary Integrin

Integrins are transmembrane proteins that play a crucial role in cell adhesion, signaling, and communication within the extracellular matrix. In the context of hair biology, integrins are involved in the regulation of hair follicle development, cycling, and the interaction between hair follicle cells and their surrounding environment. Their relevance to hair loss lies in their influence on the health and function of hair follicles; disruptions in integrin signaling can contribute to conditions such as alopecia and other forms of hair thinning. Key distinguishing characteristics of integrins include their ability to bind to specific ligands and their role in mediating cellular responses to mechanical and biochemical signals.

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research Targeting integrin pathways: mechanisms and advances in therapy

54 citations , January 2023 in “Signal Transduction and Targeted Therapy”

This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.

research α3β1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis

45 citations , May 2003 in “Journal of Cell Science”

This study found that α3β1-integrin is crucial for maintaining normal hair follicle morphology in mice, as its deficiency leads to severe abnormalities despite not affecting interfollicular epidermal differentiation.

research β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny

20 citations , December 2013 in “PLoS ONE”

This study found that β1 integrin-mediated signaling is crucial for the survival, adhesion, and migration of epithelial progenitor cells in human scalp hair follicles, with varying responses observed among cell subpopulations.

research β1 Integrins with Individually Disrupted Cytoplasmic NPxY Motifs Are Embryonic Lethal but Partially Active in the Epidermis

17 citations , May 2013 in “Journal of Investigative Dermatology”

Mutations in β1 integrins cause embryonic death but have milder effects on skin.

research The microanatomy of the distal arrector pili: possible role for α1β1 and α5β1 integrins in mediating cell‐cell adhesion and anchorage to the extracellular matrix

15 citations , February 2000 in “Journal of Cutaneous Pathology”

This study suggests that the anchorage of the arrector pili muscle to the extracellular matrix is likely mediated by α5β1 integrin, with α1β1 integrin involved in muscle cell-cell adhesion.

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community INTEGRITY ISSUE - Melissa Toyos Verteporfin Treatment Marketing

14 upvotes 1 month ago

Concerns about the integrity of Dr. Melissa Toyos' marketing for Verteporfin treatment, suggesting photos may be digitally altered. Users express skepticism about the treatment's promotion and results.

community Scalp barrier integrity and its potential link to hair follicle health

in Technology 1 upvotes 5 months ago

A healthy scalp barrier is crucial for hair growth, and ceramides may play a key role in maintaining it. The conversation suggests that focusing on scalp health, alongside treatments like Minoxidil, Finasteride, and RU58841, could improve hair follicle health.

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