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    Did you mean 5α-reductase inhibition?
    Glossary5α-reductase inhibition

    blocking enzyme that converts testosterone to hair-loss hormone DHT

    5α-reductase inhibition refers to the process of blocking the enzyme 5α-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). DHT is a hormone that can contribute to hair loss and conditions like benign prostatic hyperplasia. By inhibiting this enzyme, medications like finasteride and dutasteride can help reduce hair loss and treat these conditions.

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      Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

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      natural substance from Neem tree with medicinal and pesticidal properties

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 6 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 2.5 months topical minoxidil Progress

      in Progress Pictures  439 upvotes 1 year ago
      The conversation is about a user's hair regrowth after 2.5 months using topical minoxidil. Some suggest adding finasteride for long-term results, while others share their experiences with side effects or alternative treatments like dermarolling and dietary improvements.

      community Approximation of Scalp DHT Suppression Between 0.05 mg to 2.5 mg

      in Research/Science  63 upvotes 1 year ago
      The conversation discusses the effectiveness of various doses of Dutasteride in reducing scalp DHT and its impact on hair count. Users shared personal experiences with hair loss treatments, including Dutasteride, Finasteride, and Minoxidil, with one reporting significant hair loss reduction using a combination of oral Dutasteride and topical Minoxidil and Finasteride.