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    Did you mean 5α-reductase inhibition?
    Glossary5α-reductase inhibition

    blocking enzyme that converts testosterone to hair-loss hormone DHT

    5α-reductase inhibition refers to the process of blocking the enzyme 5α-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). DHT is a hormone that can contribute to hair loss and conditions like benign prostatic hyperplasia. By inhibiting this enzyme, medications like finasteride and dutasteride can help reduce hair loss and treat these conditions.

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      Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

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      acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

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      natural substance from Neem tree with medicinal and pesticidal properties

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      a natural and far less effective alternative to Finasteride

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      by nkrata in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 22 | ~34 Months Finasteride Update

      in Progress Pictures  818 upvotes 1 year ago
      A user shared their 34-month update on using finasteride for hair loss, noting they maintained regrowth even after stopping minoxidil a year ago. Other users shared similar experiences and expressed admiration for the results.

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 1 year ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

      community Is getting on Dut at 21 a bad idea after taking Fin since 18?

      in Chat  7 upvotes 1 year ago
      A user is considering switching from finasteride to dutasteride for hair loss at age 21, worried about potential side effects on bone and brain development. Another user shared their positive experience with dutasteride, noting minimal body hair and no side effects.