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Research

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research Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis

138 citations , April 2003 in “Carcinogenesis”

This study found that 2-methoxyestradiol induces apoptosis in human prostate cancer cells by activating p53 through a pathway dependent on p38/JNK-mediated NFkappaB/AP-1 activation, with JNK-dependent Bcl-2 phosphorylation also playing a critical role.

research BCL-2 and Bax Expression in Skin Flaps Treated with Finasteride or Azelaic Acid.

7 citations , January 2012 in “PubMed”

In this study, azelaic acid 20% and finasteride increased BCL-2 protein expression and decreased bax protein expression in rats after skin flap surgery, suggesting a potential antiapoptotic role in reducing ischemia-induced damage.

research Nutraceutical Intervention of Seeds in the Treatment of Poly Cystic Ovarian Syndrome; A Systematic Review

1 citations , December 2021 in “Pakistan biomedical journal”

This review explores the effectiveness of seed cycling, a modern alternative medicine approach, in treating polycystic ovary syndrome and reports no new clinical results.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

This study found that in estrogen receptor-positive breast cancer cells, 17β-estradiol repressed polyamine oxidase transcription by interacting with AP-1 sites on its promoter.

Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart

research Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

47 citations , May 2020 in “Cardiovascular Research”

This review explores how sex differences influence the pathophysiology, incidence, and treatment outcomes of ischaemic heart disease, and emphasizes the need for more sex-specific research.

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Community Join

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community 2 months update: Topical Minoxidil

18 upvotes 2 days ago

The user experienced significant hair regrowth and density improvement using topical Minoxidil, Trioxidil shampoo, and Foligain supplements. They are considering adding finasteride to their treatment.

community 2 months on 1mg Fin and 3mg Minoxodil

11 upvotes 5 days ago

The user is experiencing new hair growth at the temples after 2 months of using 1mg finasteride and 3mg minoxidil. Others are optimistic about the progress and encourage patience.

community 2 year update: 1.2mg Fin, 3mg Min

1100 upvotes 1 week ago

The user experienced diffuse hair loss and successfully regrew thicker hair using 1.2mg Finasteride and 3mg Minoxidil over two years. They noticed significant progress around the six-month mark and used Hims for their medication.

community 2 months only Topical Minoxidil progress

5 upvotes 1 week ago

The user reported progress with topical Minoxidil after two months, experiencing no side effects or significant shedding. Another user suggested adding finasteride for better results.

community 2 years apart. 0.5mg Dut, 2.5mg oral minox. HT at 1.2 years ; Age 26->28

181 upvotes 2 weeks ago

The user improved their hair with 0.5mg dutasteride, 2.5mg oral minoxidil, and a hair transplant of 2500 grafts in the frontal area over two years. They reported no significant side effects from the medication, except for reduced sexual function.

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Learn

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learn 2-deoxy-D-Ribose

learn octapeptide-2

learn 1,2-Hexanediol

learn ceramide 2

learn Minoxidil

Minoxidil 2%, 5% and 10% which is better to use? In a randomized trial in men, 5% topical minoxidil produced more hair growth than 2%. There is no approved 10% product and no head-to-head trial showing it beats 5%; higher strengths mainly add irritation and systemic absorption. Approved strengths differ by sex, so check the label for your product.

learn Procyanidin B-2

learn Ketoconazole

Is there a difference between 1% and 2% ketoconazole? The documented differences are strength and supply: 1% ketoconazole shampoo is sold over the counter while 2% is usually prescription-only, and almost all of the trial evidence — including a 2015 Cochrane review — was gathered on the 2% shampoo rather than in a head-to-head comparison of the two strengths.

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