Finasteride Blocks Progesterone Synthesis in MA-10 Leydig Tumor Cells

October 1993 in “ Endocrinology ”

D.A. Freeman, Peter Gocze, Z. Porpaczy

New to Finasteride? There is a guide in the encyclopedia. Read the guide →

finasteride progesterone synthesis MA-10 Leydig tumor cells cholesterol side-chain cleavage steroidogenesis 5a-reductase inhibitors Propecia

Studysummary In this study, researchers found that finasteride inhibits progesterone synthesis by blocking cholesterol side-chain cleavage in mouse-derived MA-10 Leydig cells, but this effect may not be evident in human or rat cells.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on academic.oup.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Finasteride blocks progesterone synthesis in MA-10 Leydig tumor cells

3 citations , October 1993 in “Endocrinology”

In this study, finasteride inhibited progesterone synthesis in mouse-derived MA-10 Leydig tumor cells by blocking cholesterol side-chain cleavage, but human and rat cells showed minimal sensitivity.

research Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors

19 citations , March 2010 in “Steroids”

This study found that specific steroids, particularly 5 and 7b, decreased growth of prostate and seminal vesicles and bound to the androgen receptor, showing comparable pharmacological activity to finasteride.

research Progesterone-induced spike-wave discharges are inhibited by finasteride

January 2004 in “Data Archiving and Networked Services (DANS)”

This study found that finasteride blocked the progesterone-induced increase in spike-wave discharges in rats, suggesting that this effect of progesterone is mediated by its metabolite allopregnanolone.

New Progesterone Esters as 5α-Reductase Inhibitors

research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.

22 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.

Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

research Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride

21 citations , January 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

In this study, researchers demonstrated that in a mouse model, the stimulation of mammary tumor growth due to progesterone is primarily caused by its metabolite, 5αP, not progesterone itself.