Preparation and Optimization of Aloe Ferox Gel Loaded with Finasteride-Oregano Oil Nanocubosomes for Treatment of Alopecia

    January 2022 in “ Drug Delivery ”
    Khaled M. Hosny, Waleed Y. Rizg, Eman Hassan Abdullah Alfayez … Alshaimaa M. Almehmady
    Studysummary This study investigated a finasteride and oregano oil-loaded nano-cubosome gel formulation, finding it enhanced drug release and skin permeation and demonstrated synergistic antibacterial effects, suggesting potential for treating alopecia areata.
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    Research cited in this study 10

    1. The Potential Relevance of the Microbiome to Hair Physiology and Regeneration: The Emerging Role of Metagenomics Biomedicines · 2021
    2. Alopecia and Microbiome: Future Therapeutic Target? Actas Dermo-Sifiliográficas · 2021
    3. Enhancement of Dermal Delivery of Finasteride Using Microemulsion Systems Advanced Pharmaceutical Bulletin · 2019
    4. Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath ˜The œjournal of pharmacology and experimental therapeutics/˜The œJournal of pharmacology and experimental therapeutics · 2019
    5. Alopecia Areata: A Review Journal of the Saudi Society of Dermatology & Dermatologic Surgery · 2013
    6. Is Propionibacterium Acnes Associated With Hair Casts And Alopecia? International Journal of Trichology · 2012
    7. Androgen Dependence of Hirsutism, Acne, and Alopecia in Women Medicine · 2009
    8. Finasteride Is the Main Inhibitor of 5α-Reductase Activity in Microdissected Dermal Papillae of Human Hair Follicles Archives of Dermatological Research · 1999
    9. Finasteride Drugs · 1999
    10. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994

    Related research 1

    1. Effect of Oil, Water, and Surfactant Mixture on the Physicochemical Properties and Transdermal Delivery of Finasteride-Loaded Microemulsions: Evaluation and Prediction Using Response Surface Methodology Isan Journal of Pharmaceutical Sciences · 2017