The Effect of Alfacalcidiol and Metformin on Metabolic Disturbances in Women with Polycystic Ovary Syndrome

    Jana Figurová, Ingrid Dravecká, Jana Petríková … Ivica Lazúrová
    Studysummary This randomized clinical trial found that vitamin D supplementation did not significantly alter anthropometric or metabolic parameters in obese, insulin-resistant, and vitamin D-deficient women with polycystic ovary syndrome, whereas metformin effectively reduced body weight, BMI, waist circumference, total body fat, and serum glucose levels.
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    Research cited in this study 2

    1. Prevalence of Vitamin D Deficiency in Slovak Women with Polycystic Ovary Syndrome and Its Relation to Metabolic and Reproductive Abnormalities Wiener Klinische Wochenschrift · 2015
    2. Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline The Journal of Clinical Endocrinology and Metabolism · 2006