Structural Perspectives on the Androgen Receptor, the Elusive Shape-Shifter

    August 2024 in “ Steroids ”
    Madisyn J Johnson, Elizabeth V. Wasmuth
    Studysummary This review summarizes structural insights into androgen receptor dynamics, highlighting its flexibility in binding numerous partners, which may explain adaptive resistance mutations in cancer and loss of function in androgen insensitivity syndrome.
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    Research cited in this study 2

    1. Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators Journal of medicinal chemistry · 2004
    2. Discovery of Nonsteroidal Androgens Biochemical and biophysical research communications · 1998