August 2021 in “Journal of medical science and clinical research” This case report describes an 11-month-old infant with Biotinidase deficiency who exhibited multifocal seizures, neuroregression, alopecia, and skin issues, highlighting prompt diagnosis and the dramatic clinical response to biotin treatment.
55 citations
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July 1983 in “Journal of the American Academy of Dermatology” This case study of three siblings highlights the importance of recognizing dermatologic signs—alopecia and periorificial dermatitis—for early diagnosis and treatment of biotin-responsive multiple carboxylase deficiency.
6 citations
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September 1996 in “Journal of the European Academy of Dermatology and Venereology” This study found that biotin supplementation improved biotinidase activity and led to clinical remission in some patients with alopecia areata.
4 citations
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January 2015 in “Journal of microbial & biochemical technology” In this study, the researchers observed that biotin administration in biotin-deficient children with alopecia eliminated certain membrane proteins from their blood, suggesting that biotin might regulate these proteins' expression.
1 citations
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September 1996 in “Journal of the European Academy of Dermatology and Venereology” In this study, biotin supplementation improved biotinidase activity and led to clinical remission in some patients with alopecia areata.