Effects of Yiqi Huayu Chinese Medicine on the Expression of MMP-2/TIMP-2 in BPH Rats

    January 2011 in “ Zhonghua zhongyiyao xuekan ”
    Weidong Ni
    TLDR Yiqi Huayu medicine can effectively reduce BPH in rats by lowering MMP-2 levels and blood vessel growth.
    The study investigated the effects of Yiqi Huayu Chinese medicine on benign prostatic hyperplasia (BPH) in rats, focusing on the expression of MMP-2 and TIMP-2. Fifty SD rats were used, and after 30 days of treatment with Yiqi Huayu or finasteride, results showed that the prostate index (PI), microvessel density (MVD), and MMP-2 levels were significantly lower in the treatment groups compared to the model group. The Yiqi Huayu treatment was as effective as finasteride in reducing these levels, with a notably lower MVD compared to the finasteride group. The study concluded that Yiqi Huayu could inhibit BPH, potentially by restraining MMP-2 levels and renewing blood vessels.
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