Resident CD34-Positive Cells Contribute to Peri-Endothelial Cells and Vascular Morphogenesis in Salivary Gland After Irradiation

This study found that radiation-induced salivary gland dysfunction in mice involves microvascular damage mediated by ceramide and reactive oxygen species, suggesting ROS scavengers could protect salivary function during radiotherapy for head and neck cancer.

This study found that CD34+ cells from adipose tissue may enhance hair morphogenesis and participate in blood vessel formation in reconstituted skin tissues of mice.

In this laboratory study, researchers observed that mouse vascular endothelial cells exhibit dynamic changes after exposure to ionizing radiation, including a transient endothelial subpopulation that facilitates vascular-epidermal communication and skin repair, with shifting roles in angiogenesis and immune surveillance over time.

This study developed a mouse model to simulate chronic radiation-induced salivary dysfunction, revealing dose-dependent saliva reduction and glandular changes, which may help advance salivary regenerative therapies.

This study found that exosomes derived from human amniotic mesenchymal stem cells enhanced stem cell proliferation and structural restoration in irradiated salivary glands of rats, with significant improvements observed by day 7, suggesting activation of the Wnt signaling pathway.