Unexpected Effect of Baricitinib Use: Observation of a Case of Hypertrichosis

March 2026 in “ Indian Journal of Dermatology ”

Marco Greco, Camilla Chello, Maria Cristina Acri, Alfredo Rossi, Teresa Grieco, Giovanni Pellacani

baricitinib JAK1/2 inhibitor alopecia areata hypertrichosis JAK/STAT pathway Wnt/β-catenin pathway hair follicle dynamics

From the encyclopedia

Baricitinib →

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study documented a case where the medication baricitinib effectively promoted hair regrowth in a woman with alopecia areata but also led to an unexpected side effect of hypertrichosis, suggesting a need to further explore the JAK/STAT pathway's role in hair growth dynamics.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Baricitinib: A Review in Severe Alopecia Areata

1 citations , June 2023 in “American Journal of Clinical Dermatology”

In two phase 3 clinical trials, this study found that adults with severe alopecia areata receiving baricitinib experienced significant hair regrowth on the scalp, eyebrows, and eyelashes over 36 weeks compared to placebo, although longer-term data are needed to fully assess benefits and risks.

research Hirsutism, Normal Androgens, and Diagnosis of PCOS

63 citations , August 2022 in “Diagnostics”

This review discusses hirsutism in women with PCOS who present with normal androgen levels and highlights diagnostic challenges, reporting no new clinical findings.

research The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

46 citations , June 2015 in “Journal of Investigative Dermatology”

This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.