Atopic Dermatitis And Multilocular Alopecia Areata Simultaneously Treated With Baricitinib

February 2023 in “ Actas Dermo-Sifiliográficas ”

M. Pestana, M. Brito Caldeira, B. Duarte

baricitinib JAK inhibitor alopecia areata atopic dermatitis dupilumab seborrhea

From the encyclopedia

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary Baricitinib effectively improved both atopic dermatitis and alopecia areata symptoms in a patient.

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Research cited in this study

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research Immunological Properties of Atopic Dermatitis-Associated Alopecia Areata

57 citations , March 2021 in “International Journal of Molecular Sciences”

This study found that type 2 immunity may play a role in the development of alopecia areata in patients with extrinsic atopic dermatitis, indicating different immunological states compared to non-atopic patients.

research Alopecia Areata: A Review of Disease Pathogenesis

191 citations , May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.