Mask-Free Generation of Multicellular 3D Heterospheroids Array for High-Throughput Combinatorial Anti-Cancer Drug Screening

    September 2019 in “ Materials & Design ”
    Wenguang Yang, Shuxiang Cai, Zheng Yuan … Lianqing Liu
    Studysummary This study developed a new mask-free method using digital micromirror and microfluidic systems to create multicellular heterospheroids for drug screening, finding that heterospheroids exhibit higher drug resistance and combinatorial drugs are more effective than single drugs in cancer therapeutic applications.
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    Research cited in this study 1

    1. Bottom-Up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration Advanced Healthcare Materials · 2017