Butyrophilin-Like 2 to the Rescue: Controlling Autoaggressive Dermal Gamma Delta T Lymphocytes in Human Hair Follicles

    November 2025 in “ The Journal of Immunology ”
    Natasa Strbo, Jennifer Gherardini, Laura Padula … Ralf Paus
    Studysummary This study observed that in human scalp hair follicles, BTNL2 expression is lower in stressed conditions, which correlates with increased cytotoxic activity by gamma/delta and CD8+ T cells, suggesting a possible role for BTNL2 in controlling immune responses relevant to alopecia areata.
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