Datasheet 2: Vitiligo - An Autoimmune Skin Disease and Its Immunomodulatory Therapeutic Intervention

    December 2021 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Wei-Ling Chang (11833265), Woan-Ruoh Lee (743713), Yung-Che Kuo (175057), Yen-Hua Huang (409275)
    TLDR New therapies like JAK inhibitors and stem cells show promise in treating vitiligo.
    Vitiligo is a chronic autoimmune skin disorder characterized by the loss of functional melanocytes, with immune T cells, particularly CD8+ cytotoxic T cells and regulatory T cells, playing a significant role in its pathogenesis. Recent advancements in understanding the disease have led to the development of targeted therapies, such as Janus kinase (JAK) inhibitors, which have shown therapeutic significance. Additionally, mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have emerged as promising treatments due to their ability to regulate cytokine secretion and T-cell balance, offering anti-inflammatory effects. The document highlighted the progress in these therapies and emphasized the need for further research into vitiligo treatment.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 9 results

      community fin 0.5 mg everday 6 months update

      in Finasteride/Dutasteride  28 upvotes 2 years ago
      The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

      community 1 Month Topical Minoxidil Only

      in Progress Pictures  72 upvotes 2 years ago
      The conclusion of the conversation is that the user plans to use topical minoxidil, ketoconazole shampoo, and a derma stamp for hair loss treatment. They also plan to start using finasteride in the next 2 months. Other users suggest using finasteride and a hair transplant for better results. The user appreciates the feedback and will continue posting progress.

      community 25M Exploring Causes of Hair Loss: TE, Alopecia, or AGA?

      in General  226 upvotes 2 months ago
      The user is experiencing hair loss with possible causes including chronic telogen effluvium, diffuse alopecia areata, and androgenic alopecia. They have tried treatments like Nizoral shampoo, minoxidil, and finasteride, and are considering a biopsy for further clarity.

      community One full year of treatment before and after

      in Progress Pictures  19 upvotes 1 year ago
      A user shared their one-year progress with hair loss treatment, using topical minoxidil, 2% keto shampoo, microneedling, and finasteride. They plan to start dutasteride and are considering switching to oral minoxidil.

      community Fighting Hair loss AND Grey Hair

      in Treatment  19 upvotes 3 years ago
      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

    Similar Research

    5 / 1000+ results