Vitiliginous Lesions During Contact Immunotherapy for Alopecia in a Patient with Autoimmune Thyroiditis

    July 2014 in “ Our Dermatology Online ”
    Yasunobu Kato, Toshiyuki Yamamoto
    Image of study
    TLDR Contact immunotherapy can cause vitiligo in patients with autoimmune conditions.
    A 60-year-old female with autoimmune thyroiditis developed vitiliginous lesions after two months of topical squaric acid dibutylester (SADBE) treatment for alopecia. Despite initial hair regrowth, depigmentation spread beyond the application areas, suggesting an autoimmune response rather than contact leucoderma. Laboratory tests showed normal liver and renal function but elevated anti-thyroid antibodies. A skin biopsy revealed decreased melanocytes and CD8-positive T-cell infiltration. SADBE therapy was discontinued, and topical corticosteroids led to significant improvement within nine months. The case highlighted the need for caution when using contact immunotherapy in patients with autoimmune conditions.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community AGA evaluation and first steps - BEGINNER MEGAPOST

      in Chat  73 upvotes 2 months ago
      The conversation discusses androgenic alopecia (AGA) and its treatments, focusing on finasteride, minoxidil, and ketoconazole shampoo. Finasteride is recommended as essential for preventing further hair loss.

      community Not everyone should immediately go on Fin if they are starting to bald

      in Finasteride/Dutasteride  21 upvotes 10 months ago
      The conversation suggests that people should consult a dermatologist to understand their type of hair loss before starting treatments like finasteride or dutasteride, especially if they have autoimmune issues or low DHT. Some participants believe in starting treatment like finasteride immediately if hair loss is due to DHT, while others recommend ruling out other causes and considering minoxidil first, especially for younger individuals.

      community If RU58841 is such an effective anti androgen

      in Research/Science  48 upvotes 10 months ago
      RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

      community How do we only have two treatments to combat hair loss at this point in time?

      in Chat  211 upvotes 1 year ago
      The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

    Similar Research

    5 / 1000+ results
      Melanocytes and Vitiligo and Hair Graying

      research Melanocytes and Vitiligo and Hair Graying

      1 citations, January 2014 in “Elsevier eBooks”
      Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.
      Vitiligo: A Comprehensive Overview

      research Vitiligo: A Comprehensive Overview

      532 citations, August 2011 in “Journal of the American Academy of Dermatology”
      Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.
      Vitiligo

      research Vitiligo

      63 citations, December 1988 in “International Journal of Dermatology”
      Vitiligo causes white skin patches and is linked to autoimmune issues.