Visible-To-Near IR Quantum Dot-Based Hypermulticolor High-Content Screening of Herbal Medicines for Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition
April 2013
in “
SLAS discovery
”
TLDR Some herbal extracts can promote hair growth and prevent hair loss.
The study investigated the efficacy of nine herbal extracts from three different herbal medicine mixtures, using three extraction methods, for promoting hair growth and inhibiting hair loss in two cell lines. The efficacy was assessed by measuring the expression levels of five target proteins: IGF-1, TGF-β2, VEGF, DKK-1, and Wnt5α. The results were compared to minoxidil, a known hair growth promoter. Efficacy was defined by increased levels of IGF-1, VEGF, and Wnt5α, and decreased levels of DKK-1 and TGF-β2. High-content screening (HCS) with visible-to-near infrared quantum dot-based hypermulticolor imaging successfully enabled intracellular concurrent imaging of these proteins.
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