Topical 4-Aminopyridine 5% in Male Androgenetic Alopecia: A Split-Scalp Exploratory Series

January 2026 in “ Journal of Cosmetic Dermatology ”

Nicolò Rivetti, Claudio Zeccara

4-aminopyridine androgenetic alopecia microneedling hair density trichometric parameters 4-AP AGA

Studysummary In this 10-patient exploratory study, the researchers found that topical application of 4-aminopyridine 5% combined with microneedling did not improve hair density or quality in men with androgenetic alopecia, suggesting limited efficacy in this context despite promising results in animal wound models.

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research Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

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