Commentary on the Use of Platelet-Rich Plasma in Cicatricial Alopecia

The commentary from 2019 discussed the use of Platelet-Rich Plasma (PRP) as a treatment for hair loss, specifically cicatricial alopecia. It highlighted two biopsy-proven cases of primary scarring alopecia that showed improvement after three treatments of PRP. However, hair loss resumed within six months of stopping treatment, indicating the need for ongoing therapy. The mechanism of PRP in hair loss is likely due to the growth factors released by platelets, which have shown to improve the number of hair follicles, vascularity, and epidermal thickness. Despite promising results, the commentary emphasized the need for larger randomized control trials to validate the evidence, as the sample size was extremely limited. It also noted that PRP treatment yielded mixed results for patients with cicatricial alopecia, suggesting further research to understand why some patients respond to the treatment and others do not.