The Role of the TRPV4 Channel in Intestinal Physiology and Pathology

The TRPV4 channel, part of the TRP superfamily of cation channels, is activated by stimuli like heat and mechanical stress and plays a crucial role in intestinal physiology and pathology. It regulates intestinal smooth muscle contraction, mucosal barrier permeability, ion transport, and immune cell generation. Altered TRPV4 expression is linked to intestinal diseases such as IBD, IBS, and tumors, where it negatively impacts intestinal barrier function when damaged. This review highlights the potential of targeting TRPV4 for treating intestinal diseases due to its significant involvement in both physiological and pathological intestinal functions.