Trpv1 Function in Health and Disease
December 2010
in “
Current Pharmaceutical Biotechnology
”
TLDR TRPV1 is involved in pain, various body functions, and diseases, but targeting it for treatment is challenging.
The document discussed the transient receptor potential vanilloid type 1 ion channel (TRPV1), which was known for mediating burning sensations from heat and capsaicin. It highlighted TRPV1's role in inflammation-related pain and its involvement in various physiological and pathological conditions beyond pain, such as functions in the urinary tract, respiratory and auditory systems, metabolism, hair growth regulation, and cancer development. The potential for therapeutic interventions targeting TRPV1 was noted, though the widespread distribution of TRPV1 posed challenges for drug development due to possible impacts on its normal functions.