Trichohyalin Mechanically Strengthens the Hair Follicle
October 2003
in “Journal of biological chemistry/The Journal of biological chemistry”
TLDR Trichohyalin makes hair follicles stronger.
The study demonstrated that trichohyalin played a crucial role in mechanically strengthening the hair follicle's inner root sheath by acting as a multi-functional cross-bridging protein. It was shown to undergo post-synthetic modifications, including citrullination and cross-linking, which allowed it to serve three main functions: forming an interfilamentous matrix by cross-linking with keratin intermediate filaments, reinforcing the cornified cell envelope by linking with various barrier proteins, and coordinating the linkage between keratin filaments and the cell envelope. These functions collectively contributed to the mechanical strength and integrity of the hair follicle's inner root sheath.
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Cited in this study
research Epithelial barrier function: assembly and structural features of the cornified cell envelope
The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.
research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling
Cathepsin L is essential for normal hair growth and development.
research Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes
Small proline-rich proteins and trichohyalin help make epithelial tissues tougher and more flexible.
research The Fate of Trichohyalin
Trichohyalin is modified by enzymes to form strong structures in hair cells.
research Trichohyalin: A structural protein of hair, tongue, nail, and epidermis
research Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis
Trichohyalin is also found in the outer layers of normal human skin.
research Trichohyalin, an intermediate filament-associated protein of the hair follicle.
Trichohyalin is a protein in hair follicles that helps form hair filaments.
research Structural features of the α-type filaments of the inner root sheath cells of the guinea pig hair follicle
α-type filaments in guinea pig hair follicles have unique structural features.
research Formation of the iε-(γ-glutamyl)lysine crosslink in hair proteins. Investigation of transamidases in hair follicles
Transamidases help form strong crosslinks in hair proteins, crucial for hair strength.
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Only a few hair-specific keratins are linked to inherited hair disorders.
research Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles
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