TLDR Trichofolliculoma is a rare skin bump on the face or scalp.
Trichofolliculoma was described as a rare hair follicle hamartoma, often mistaken for other skin disorders due to its lack of distinctive clinical features. It typically presented as a small papule or nodule, primarily on the face and scalp, with a central pore and sometimes a tuft of vellus hairs. The case of a 19-year-old woman with a scalp nodule exemplified these characteristics, and histological examination confirmed the diagnosis. Although benign, trichofolliculoma could recur after excision, as seen in this case. The condition was believed to result from abortive differentiation of skin cells toward hair follicles, with histopathological features including a dilated central follicle and smaller secondary follicles. Malignant transformation was rare but had been reported.
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March 2003 in “British journal of dermatology/British journal of dermatology, Supplement” Trichofolliculoma has specific cytokeratin patterns that help in its diagnosis.
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August 1979 in “Archives of Dermatology” Trichofolliculomas can sometimes be more aggressive than thought.
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January 2013 in “Dermatology Online Journal” Trichofolliculoma is a rare skin bump on the face or scalp.
30 citations
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May 2010 in “British Journal of Dermatology” Intermediate hair follicles are a better model for studying hair growth and testing hair loss treatments.
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July 2008 in “British Journal of Dermatology” 138 citations
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March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
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January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.