Effect of Tribulus Terrestris Extract on Melanocyte-Stimulating Hormone Expression in Mouse Hair Follicles

    December 2006
    Yang Liu, Jianwei Lu, Jing An, Xuan Jiang
    TLDR Tribulus terrestris extract significantly increases MSH expression and melanin production in mouse hair follicles.
    The study investigated the effect of Tribulus terrestris extract on melanocyte-stimulating hormone (MSH) expression in C57BL/6J mouse hair follicles. Mice treated with the extract showed a 75% positivity rate of MSH expression in hair follicle melanocytes, compared to only 18.75% in the control group, indicating a significant increase (P<0.01). The extract was found to activate tyrosinase activity, promote melanocyte proliferation, melanin synthesis, and the epidermal migration of dormant melanocytes.
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