Effect of Tribulus Terrestris Extract on Melanocyte-Stimulating Hormone Expression in Mouse Hair Follicles

December 2006

Yang Liu, Jianwei Lu, Jing An, Xuan Jiang

Tribulus terrestris melanocyte-stimulating hormone MSH hair follicles tyrosinase melanocyte proliferation melanin synthesis epidermal migration

Studysummary In this study, oral Tribulus terrestris extract significantly increased MSH expression in mouse hair follicle melanocytes, suggesting enhanced melanocyte activity and migration.

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The study investigated the effect of Tribulus terrestris extract on melanocyte-stimulating hormone (MSH) expression in C57BL/6J mouse hair follicles. Mice treated with the extract showed a 75% positivity rate of MSH expression in hair follicle melanocytes, compared to only 18.75% in the control group, indicating a significant increase (P<0.01). The extract was found to activate tyrosinase activity, promote melanocyte proliferation, melanin synthesis, and the epidermal migration of dormant melanocytes.

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