Thiopurine-Induced Myelosuppression with Severe Sepsis in a Patient with Crohn's Disease: A Case Report

    Shubham Jain, Suhas Udgirkar, Qais Contractor … Sujit Nair
    Studysummary This case report details severe hematological toxicity and fatal complications from azathioprine in a patient with Crohn's disease with a homozygous NUDT 15 variant, suggesting pharmacogenomic testing before treatment.
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    Research cited in this study 1

    1. NUDT15 R139C-Related Thiopurine Leukocytopenia Is Mediated by 6-Thioguanine Nucleotide-Independent Mechanism in Japanese Patients with Inflammatory Bowel Disease Journal of Gastroenterology · 2015