TLDR PGC-1α may improve aging skin by boosting mitochondrial function and reducing inflammation.
This review explores the role of PGC-1α in improving the function of the aging skin barrier. Aging skin shows reduced mitochondrial function and chronic low-level inflammation, which are also observed in other aging organs. PGC-1α, a key transcriptional coactivator, is crucial for enhancing mitochondrial function and antioxidant production. The review discusses how PGC-1α might positively influence aged skin by modulating mitochondrial function and addressing oxidative stress, cellular senescence, and inflamm-aging. The mechanisms by which PGC-1α affects the aging epidermis are examined, highlighting its potential to improve skin barrier function in the elderly.
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