The Immunopathobiology of Lichen Planopilaris

    December 2011 in “ [Thesis]. Manchester, UK: The University of Manchester; 2011. ”
    Matthew Harries
    TLDR Immune system failure in hair follicles causes lichen planopilaris, leading to hair loss.
    The study investigated the collapse of immune privilege (IP) in the hair follicle bulge region in patients with lichen planopilaris (LPP), an inflammatory disorder causing permanent hair loss. The research involved biopsies from patients, analyzing gene expression and immune cell presence. Results showed increased expression of immune markers and reduced immunosuppressants, indicating IP collapse. This was associated with a loss of epithelial hair follicle stem cells (eHFSC) and increased immune cell infiltration, particularly T-cells, mast cells, and macrophages. The pro-inflammatory cytokine interferon-γ was found to exacerbate IP collapse. The study concluded that IP collapse in bulge cells is a key factor in LPP, with interferon-γ playing a significant role, and suggested further research to identify triggers of IP collapse.
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