The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway

The study identified quercitrin, a flavonol, as a novel enhancer of the Wnt/β-catenin signaling pathway by inhibiting GSK3 activity, which is crucial for cell proliferation, differentiation, and synapse maintenance. Quercitrin's effects were demonstrated in various models, including cell assays and animal models like mice and Xenopus laevis, where it increased β-catenin stabilization and synaptogenesis. In mice, quercitrin rescued memory impairment and synapse loss induced by amyloid-β oligomers, suggesting its potential as a therapeutic candidate for Alzheimer's disease. The study highlighted quercitrin's ability to enhance Wnt signaling without promoting tumorigenesis, making it a promising candidate for further research in treating neurodegenerative diseases.