The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial

    August 2003 in “British Journal of Dermatology
    R. S. Berger, J. L. Fu, Kenneth A. Smiles, C. B. Turner, B. M. Schnell, K. M. Werchowski, Karen M. Lammers
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    TLDR Minoxidil and pyrithione zinc combo most effectively increases hair density.
    A 6-month randomized controlled trial was conducted on 200 healthy men with Hamilton-Norwood type III vertex or type IV baldness to assess the hair growth benefits of a 1% pyrithione zinc shampoo compared to a 5% minoxidil topical solution, a placebo shampoo, and a combination of the two. Hair count results showed a significant increase in total visible hair counts for the 1% pyrithione zinc shampoo, the 5% minoxidil topical solution, and the combination treatment groups relative to the placebo shampoo after 9 weeks of treatment. The study concluded that daily use of a 1% pyrithione zinc shampoo over a 26-week treatment period can result in a modest and sustained improvement in hair growth. The combination of minoxidil and pyrithione zinc was found to be more effective in increasing hair density than either treatment alone.
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