Targeting NETosis to Treat Delayed Wound Healing in a Humanized Mouse Model of Sickle Cell Disease

    November 2024 in “ Journal of Investigative Dermatology ”
    Quang Chi Ngo, Mansour Alkobtawi, Lakshmi Sandhow, Shreen Matar, C. Al Youssef, Diana Passaro, Tallya Maciel, Olivier Hermine, S. Aractingi, Bénédicte Oulès
    TLDR Reducing neutrophils or inhibiting NETs improves wound healing in sickle cell disease.
    This study investigates the role of neutrophils and neutrophil extracellular traps (NETs) in delayed wound healing in sickle cell disease (SCD) using the humanized Townes mouse model. Sickle cell mice (SS) exhibited delayed skin healing, reduced neo-epidermis formation, and angiogenesis compared to control mice (AA), despite no major architectural skin differences. SS mice had more circulating neutrophils and increased bone marrow hematopoietic stem and progenitor cells. Neutrophils in SS mice were more activated, releasing more NETs, which were also elevated in the wound bed. Treatments reducing neutrophil counts or inhibiting NETs, such as hydroxyurea, DNAse, or PAD4 inhibitors, improved wound healing. Grafting experiments confirmed that delayed healing was due to defects in bone marrow-recruited cells. The study highlights the pathogenic role of neutrophils and NETs in impaired wound healing in SCD.
    Discuss this study in the Community →

    Related Community Posts Join

    4 / 4 results

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  417 upvotes 10 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community I got my bloodwork done... What now?

      in Update  6 upvotes 2 months ago
      The user has been experiencing hair thinning despite taking finasteride and minoxidil for six months. Bloodwork suggests a vitamin D deficiency, and users recommend consulting a doctor and possibly supplementing vitamin D.

      community Hair is kinking rapidly following hair loss

      in Update  1 upvotes 7 months ago
      Hair loss has slowed, but uneven growth and kinking persist despite using keto/nizoral shampoo and clotrimazole. Stress and anxiety might be contributing factors.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Similar Research

    5 / 1000+ results