Trichosanthes Kirilowii Extract Promotes Wound Healing Through the Phosphorylation of ERK1/2 in Keratinocytes

The study found that Trichosanthes kirilowii (TK) extract significantly promoted keratinocyte proliferation and enhanced wound healing both in vitro and in vivo, primarily through the phosphorylation of ERK1/2. The extract increased the expression of key growth factors and proliferation markers, contributing to improved wound closure. Active compounds like gentisic acid and hesperetin were identified as playing crucial roles in these processes. The research suggested that TK extract could be a promising plant-derived therapeutic agent for wound healing, with potential applications in skin care and pharmaceuticals.