Overlapping Primary and Secondary Syphilis in HIV Patient

    July 2020 in “ Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya ”
    Nurul Laili Nahlia, Lita Setyowatie
    This case study reported on a 55-year-old HIV-positive man with overlapping primary and secondary syphilis, highlighting the varied clinical manifestations due to compromised immune responses. The patient, with a history of multiple sexual partners and infrequent condom use, presented with non-scarring alopecia, a painless ulcer, and various skin lesions. Diagnostic tests confirmed syphilis and HIV, with a low CD4 T-cell count of 111 cells/µL. Treatment with benzathine penicillin G and antiretroviral drugs led to significant improvement, as evidenced by a non-reactive VDRL test and an increased CD4 count of 325 cells/µL after six months. This case demonstrated that prompt antibiotic and antiretroviral treatment could effectively improve both clinical and serological outcomes in HIV patients with syphilis co-infection.
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