TLDR Using Eflornithine cream with laser treatments improves facial hair removal.
The chapter discussed the combined use of Eflornithine cream and laser/light-based systems for hair management, highlighting the potential for enhanced effectiveness in facial hair removal. Eflornithine, an inhibitor of ornithine decarboxylase, played a role in reducing hair growth by affecting polyamine synthesis, which is crucial for cellular proliferation. Despite the benefits, factors such as cost, inconvenience, limited efficacy, and skin safety risks, particularly in facial areas, hindered its acceptability. The combination of Eflornithine (Vaniqa) with laser treatment showed a synergistic effect, potentially overcoming the limitations of each method alone and improving consumer satisfaction by reducing the risk of dermal damage and addressing the challenges posed by different hair types and pigmentation.
125 citations,
February 2007 in “Journal of the American Academy of Dermatology” Combining eflornithine cream with laser treatment removes facial hair better than laser alone.
46 citations,
January 2000 in “The Journal of Clinical Endocrinology and Metabolism” 24 citations,
June 1999 in “Mechanisms of Development” Ornithine decarboxylase is crucial for hair growth and follicle development.
27 citations,
November 1998 in “Journal of Endocrinological Investigation” Finasteride significantly reduces hair growth in women with idiopathic hirsutism.
76 citations,
December 1997 in “Fertility and Sterility” Finasteride reduces hair growth better, but spironolactone has more side effects.
42 citations,
February 1996 in “Journal of Investigative Dermatology” Polyamines, especially spermidine, are essential for hair growth.
34 citations,
January 1995 in “The Journal of Clinical Endocrinology and Metabolism” 33 citations,
March 1994 in “PubMed” High ODC and low K1 and K10 may indicate early skin tumors in mice.
43 citations,
December 1993 in “Annals of internal medicine” Flutamide, a medication used for excessive hair growth, can cause severe liver damage in women.
78 citations,
May 1989 in “The Journal of Clinical Endocrinology & Metabolism” Spironolactone effectively reduces hair growth in women with hirsutism and is generally well-tolerated.
124 citations,
September 1980 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Spironolactone is effective in treating excessive hair growth in women.
34 citations,
October 1975 in “Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis”
October 2006 in “Dermatologic Surgery” Combining eflornithine cream with laser therapy effectively reduces unwanted facial hair in women.