Androgenetic Alopecia Is Not Associated With Major Vascular Comorbidities: A Retrospective Case-Control Study of 8230 Patients

    December 2024 in “ JEADV Clinical Practice
    Michael M Ong, Steven Zeldin, Brian Stone, Shari R. Lipner
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    TLDR Androgenetic alopecia is linked to a higher risk of varicose veins, especially in men, but not to major vascular diseases.
    This retrospective case-control study of 8,230 patients found that androgenetic alopecia (AGA) is not associated with an increased risk of major vascular diseases like hypertension and coronary artery disease. However, there is a notable increased risk of varicose veins in AGA patients, especially in men, with an adjusted odds ratio of 3.22 for overall AGA and 10.70 for early onset AGA. The study suggests that this risk may be linked to androgenic activity rather than cardiovascular mechanisms. Despite its limitations, such as the retrospective design and a small number of early onset cases, the study recommends that dermatologists discuss potential vascular comorbidities with male patients with early-onset AGA and consider routine cardiovascular health screenings. Further prospective studies are needed to better understand the relationship between AGA severity, sex, and vascular risk, as well as the role of lifestyle factors.
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